COX and cancer
نویسندگان
چکیده
منابع مشابه
Cox and Frailty Models for Analysis of Esophageal Cancer Data
By existing censor and skewness in survival data, some models such as weibull are used to analyzing survival data. In addition, parametric and semiparametric models can be obtained from baseline hazard function of Cox model to fit to survival data. However these models are popular because of their simple usage but do not consider unknown risk factors, that's why cannot introduce the be...
متن کاملCOX-2 Inhibitors and Gastric Cancer
The evidence that cyclooxygenase-2 (COX-2) is upregulated and plays an important role in carcinogenesis of gastric cancer has triggered the topic of COX-2 inhibitors as chemopreventive agents for gastric cancer. Studies find that COX-2 inhibitors are associated not only with chemoprophylactic effects, but also with chemotherapeutic potentials in gastric cancer. Both COX-dependent and COX-indepe...
متن کاملCOX-2 inhibitors and breast cancer.
The cyclooxygenase ( COX ) -2 inhibitor celecoxib was recently approved in the USA for the prevention of polyp formation in familial adenomatous polyposis, a defined premalignant condition for colorectal cancer. The potential value of COX inhibitors in similar roles for other malignancies, particularly breast cancer, is therefore currently under intense scrutiny. Use of these medications in che...
متن کاملEvaluation of Expression of EGFR, HER-2 and COX-2 in Colorectal Cancer
Background and objective: EGFR and HER-2 are two members of ERbB/HER family of Type I Transmembrane growth factor receptors. Cox2 is an enzyme responsible for the conversion of arachidonic acid to prostaglandins, which has a major role in angiogenesis and can modelate tumor growth. The aim of this study was to determine the level of expression of EGFR, HER-2 and Cox2 in colorectd cancer. Mater...
متن کاملAdditive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro.
We hypothesized that combined treatment with Cox-1 and Cox-2 specific inhibitiors would exhibit synergistic effects against breast cancer in vitro. Two human breast cancer cell lines (HTB26, MCF-7) were treated with catechin (Cox-1 inhibitor) or NS398 (Cox-2 inhibitor) at 100 microM as both single and combined treatments. Reductions in cell growth were observed in both cell lines at 24 and 72 h...
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ژورنال
عنوان ژورنال: QJM: An International Journal of Medicine
سال: 2005
ISSN: 1460-2393,1460-2725
DOI: 10.1093/qjmed/hci119